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This information will be published in the funding statement if the manuscript is accepted.

If the funders had no role, answer No to this question.

We encourage authors of Essays to select the most representative references to convey their points and avoid exhaustively covering the relevant literature. They might: Our Essays aim to engage a broad and diverse audience—it is therefore important to ensure that they are written in an accessible, semi-journalistic style that captures the interest of both specialists and non-specialist readers.

We encourage the use of figures to illustrate key concepts in a lively, easy to grasp manner; as well as the use of text boxes for background, self-contained information.

They address issues at the interface between science and policy or science and society; present a policy position aimed at influencing policy decisions; examine and make recommendations on scientific and publishing practices.

The ideal Perspective conveys a sense of urgency—why is this topic of immediate concern?The majority of articles in the magazine are published by invitation only, but if you have a suggestion for a topic in any of our current magazine categories, we will consider the idea. If you have any questions about submitting an idea or article for consideration in the magazine section, email our editorial office, [email protected] audience of our magazine is very broad, including students, scientists, and the educated general reader.magazine is inclusive and accessible to a broad audience.Magazine articles are directed at a readership that extends beyond the traditional research community and includes scientific educators, students, physicians, patients, and the interested public. Before submitting, consult our General Guidelines for Magazine Submissions, as well as the guidelines for the specific article type you are interested in.Unsolved Mysteries are peer-reviewed and commissioning does not guarantee publication.Example Unsolved Mysteries Patel AD (2014) The Evolutionary Biology of Musical Rhythm: Was Darwin Wrong? https://doi.org/10.1371/1001821​ Pitt JN, Kaeberlein M (2015) Why Is Aging Conserved and What Can We Do about It? https://doi.org/10.1371/1001821​ The “Perspectives” section provides experts with a forum to comment on topical or controversial issues of broad interest.“Essays” are opinionated articles on a topic of interest to scientists, as well as to a broader audience, including the general public.Unlike traditional review articles, which include a comprehensive account of a field, Essays take an imaginative approach to a provocative question, with an engaging though rigorous investigation of the problem.Essays are peer-reviewed and commissioning does not guarantee publication.Editors work closely with authors to ensure that articles are written in an engaging, succinct, yet rigorous manner.

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