Coagulation tests revealed a shortened thromboplastin time (TT), long PT time, low level of coagulation factor II, and positive lupus anticoagulant among the antiphospholipid antibodies.
In one patient the clinical symptoms disappeared during a one-week course of prednisolone, another one received a prothrombin complex preparation as substitution therapy.
Spontaneous bleeding from the nose, mouth or digestive tract may not indicate any serious condition; but sometimes it can be severe enough to be life-threatening.
Normally when a person gets injured and bleeding occurs, a blood clot is formed to stop the bleeding.
Bleeding disorders are characterized by defects in hemostasis that lead to an increased susceptibility to bleeding (also known as hemorrhagic diathesis).There are several substances present in the body, like platelets and clotting factors that aid in this process.When there is a bleeding disorder, the clotting mechanism fails due to several reasons.Iron Supplementation As there is a significant loss of iron during bleeding diathesis, iron supplements may be used to replenish the amount of iron in the body.Low iron levels or its deficiency can result in iron deficiency anemia.Defects in blood vessels manifest as red or purple spots and patches on the skin, rather than bleeding.The underlying abnormalities are either in the vessels themselves or in the perivascular connective tissue.In the third patient the symptoms were milder and vanished without any specific treatment.The levels of coagulation factor increased in all patients and the lupus anticoagulant disappeared within a couple of months.Acquired disorders occur due to: Consuming anticoagulants (drugs that inhibit clotting) including heparin, warfarin, or direct oral anticoagulants (DOACs) (including dabigatran, apixaban, edoxaban, and rivaroxaban) DIC if it progresses slowly Liver disease (the liver is a major site of blood clotting factor production, and helps to regulate blood clotting, and so people with liver disease (for example, hepatitis or cirrhosis) have a tendency to bleed easily)Vitamin K deficiency Antibodies against factor VIII (or other factors)Massive transfusion Thrombocytopenia Hereditary disorders occur due to Hemophilia, a hereditary disorder in which the body does not make enough of certain clotting factors.People have excessive bleeding into deep tissues such as muscles, joints, and the back of the abdominal cavity, usually following minor trauma.